Matteson E L, Gold K N, Bloch D A, Hunder G G
Division of Rheumatology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
Am J Med. 1996 Aug;101(2):129-34. doi: 10.1016/s0002-9343(96)80066-0.
To determine survivorship in Wegener's granulomatosis (WG) in a well-defined multicenter cohort.
Follow-up was obtained for 77 of the 85 patients enrolled in the 1990 American College of Rheumatology vasculitis classification study.
There were 28 deaths (10 females and 18 males) among the 77 patients available for follow-up. Standardized mortality ratios (SMR) were calculated with mortality data from the general population and from this group of patients with WG (an SMR of 1 indicates that expected and observed survival are identical). Overall survivorship among patients with WG was substantially reduced in this cohort (SMR = 4.685 +/- 0.65; for females SMR = 6.814 +/- 1.571; for males SMR = 3.998 +/- 0.69).
The life expectancy of patients with WG is reduced compared with the general population.
在一个明确界定的多中心队列中确定韦格纳肉芽肿（WG）患者的生存率。
对1990年美国风湿病学会血管炎分类研究中登记的85例患者中的77例进行随访。
在可进行随访的77例患者中，有28例死亡（10例女性和18例男性）。使用来自普通人群和这组WG患者的死亡率数据计算标准化死亡率（SMR）（SMR为1表示预期生存和观察到的生存相同）。该队列中WG患者的总体生存率大幅降低（SMR = 4.685 ± 0.65；女性SMR = 6.814 ± 1.571；男性SMR = 3.998 ± 0.69）。
与普通人群相比，WG患者的预期寿命缩短。
