Kloos H
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, USA.
Arch Environ Health. 1996 Jul-Aug;51(4):291-9. doi: 10.1080/00039896.1996.9936028.
Ground-water contamination with the pesticides 1,2 dibromo-3-chloropropane (DBCP) and ethylene dibromide (EDB) affects Fresno/Clovis city in California. The spatial and temporal distribution of DBCP and EDB in public wells in Fresno/Clovis was examined, using mapping and time-series analyses of chemical test results, during the time periods 1979-1980 and 1992-1993. Health risks were estimated from mean concentrations, lifetime cancer risks were estimated, and monitoring and control programs were reviewed. Mean DBCP concentrations in selected wells declined from 0.56 ppb in 1979-1980 to 0.18 ppb in 1992-1993. Closure of wells and wellhead filtration caused levels to be reduced further (i.e., to 0.06 ppb). Mean EDB concentrations declined from 0.25 ppb to 0.15 ppb during the same time periods. The estimated lifetime cancer risk for DBCP was 1 excess death per 125 000 population in 1992-1993, but this risk varied within the city. The risk for EDB was 1 excess death per 2.2 million. Recommendations were made for the modeling of pesticide movement in ground water and for epidemiological studies.
农药1,2 - 二溴 - 3 - 氯丙烷(DBCP)和二溴乙烷(EDB)对加利福尼亚州弗雷斯诺/克洛维斯市的地下水造成了污染。在1979 - 1980年和1992 - 1993年期间,通过对化学测试结果进行绘图和时间序列分析,研究了弗雷斯诺/克洛维斯市公共水井中DBCP和EDB的时空分布。根据平均浓度估算了健康风险,估算了终生患癌风险,并对监测和控制计划进行了审查。选定水井中的DBCP平均浓度从1979 - 1980年的0.56 ppb降至1992 - 1993年的0.18 ppb。关闭水井和井口过滤使浓度进一步降低(即降至0.06 ppb)。在同一时期,EDB的平均浓度从0.25 ppb降至0.15 ppb。1992 - 1993年,DBCP的终生患癌风险估计为每12.5万人中有1例额外死亡,但该风险在市内有所不同。EDB的风险为每220万人中有1例额外死亡。针对地下水中农药迁移模型和流行病学研究提出了建议。