美国药典装置1和装置2在不同转速下对烟酸制剂溶出度的影响。
Effect of USP apparatus 1 and 2 at different rotational speeds on dissolution of niacin formulations.
作者信息
Kirchhoefer R D, Hamilton J F
机构信息
U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Division of Drug Analysis, St. Louis, MO 63101, USA.
出版信息
J AOAC Int. 1996 Jul-Aug;79(4):1005-8.
PMID:8757459
Abstract
Forty-four niacin formulations were examined by the United States Pharmacopeia dissolution test, consisting of 0.1N HCl with apparatus 1 and 2. Each formulation was tested with apparatus 1 (basket) at 100 rpm and apparatus 2 (paddle) at 50 and 100 rpm. Dissolution results varied widely among manufacturers.
摘要
美国药典溶出度试验对44种烟酸制剂进行了检测，采用0.1N盐酸，使用装置1和装置2。每种制剂分别在装置1（吊篮）中以100转/分钟、在装置2（桨板）中以50转/分钟和100转/分钟进行测试。不同厂家的溶出度结果差异很大。
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