Garfein C F, Aulicino M R, Leytin A, Drossman S, Hermann G, Bleiweiss I J
Department of Pathology, Mount Sinai Medical Center, New York, NY 10029, USA.
Arch Pathol Lab Med. 1996 Jul;120(7):676-80.
We report six cases of myoid hamartoma of the breast, a rare benign lesion in which the characteristic smooth muscle cells may have epithelioid histology. We emphasize the importance of radiographic correlation and immunohistochemical studies to diagnosis, particularly on stereotactic core biopsies, to avoid potential confusion with infiltrating lobular carcinoma.
Case studies. Prospective and retrospective analysis of six cases, including stereotactic biopsy of two.
Academic medical center-based pathology practice.
Six postmenopausal women, aged 50 to 59 years, with palpable or nonpalpable mammographically evident breast masses.
All the lesions were radiographically well circumscribed, most showing heterogeneous radiodensity. Histologically variable amounts of glandular, fibrous, and adipose tissue were admixed with smooth muscle cells, which occasionally had prominent epithelioid features. All the lesions' myoid cells stained for smooth muscle markers as well as steroid receptor proteins. Stereotactic core biopsy was diagnostic in one case, making excision unnecessary.
With proper radiographic correlation and immunohistochemical confirmation, myoid hamartoma can be confidently diagnosed even on the limited tissue samples yielded by stereotactic core biopsy.
我们报告6例乳腺肌样错构瘤，这是一种罕见的良性病变，其特征性的平滑肌细胞可能具有上皮样组织学表现。我们强调影像学关联和免疫组织化学研究对诊断的重要性，尤其是在立体定向核心活检中，以避免与浸润性小叶癌产生潜在混淆。
病例研究。对6例病例进行前瞻性和回顾性分析，其中2例进行了立体定向活检。
基于学术医学中心的病理学实践。
6名绝经后女性，年龄在50至59岁之间，乳房有可触及或乳腺X线摄影显示的不可触及肿块。
所有病变在影像学上边界清晰，大多数表现为不均匀的放射密度。组织学上，不同数量的腺性、纤维性和脂肪组织与平滑肌细胞混合，平滑肌细胞偶尔具有明显的上皮样特征。所有病变的肌样细胞均对平滑肌标志物以及类固醇受体蛋白呈阳性染色。立体定向核心活检在1例中具有诊断性，无需进行切除。
通过适当的影像学关联和免疫组织化学确认，即使在立体定向核心活检获取的有限组织样本上，也能可靠地诊断乳腺肌样错构瘤。
