Jain P, Girardi L S, Sherman L, Berelowicz M, Smith L G
Department of Internal Medicine, State University of New York, Stony Brook, USA.
Postgrad Med J. 1996 Jun;72(848):365-7. doi: 10.1136/pgmj.72.848.365.
We describe a case of diabetes mellitus induced by megestrol acetate in a patient with the acquired immunodeficiency syndrome. Metabolic studies including an arginine infusion test excluded an insulinopenic state and suggested insulin resistance as the underlying mechanism for hyperglycaemia. Withdrawal of megestrol acetate resulted in rapid correction of all metabolic abnormalities and eliminated the need for exogenous insulin therapy.
我们描述了一例获得性免疫缺陷综合征患者因醋酸甲地孕酮诱发糖尿病的病例。包括精氨酸输注试验在内的代谢研究排除了胰岛素缺乏状态，并提示胰岛素抵抗是高血糖的潜在机制。停用醋酸甲地孕酮后，所有代谢异常迅速得到纠正，不再需要外源性胰岛素治疗。
