醋酸甲地孕酮治疗相关的胰岛素抵抗与糖尿病发生
Insulin resistance and development of diabetes mellitus associated with megestrol acetate therapy.
作者信息
Jain P, Girardi L S, Sherman L, Berelowicz M, Smith L G
机构信息
Department of Internal Medicine, State University of New York, Stony Brook, USA.
出版信息
Postgrad Med J. 1996 Jun;72(848):365-7. doi: 10.1136/pgmj.72.848.365.
Abstract
We describe a case of diabetes mellitus induced by megestrol acetate in a patient with the acquired immunodeficiency syndrome. Metabolic studies including an arginine infusion test excluded an insulinopenic state and suggested insulin resistance as the underlying mechanism for hyperglycaemia. Withdrawal of megestrol acetate resulted in rapid correction of all metabolic abnormalities and eliminated the need for exogenous insulin therapy.
摘要
我们描述了一例获得性免疫缺陷综合征患者因醋酸甲地孕酮诱发糖尿病的病例。包括精氨酸输注试验在内的代谢研究排除了胰岛素缺乏状态，并提示胰岛素抵抗是高血糖的潜在机制。停用醋酸甲地孕酮后，所有代谢异常迅速得到纠正，不再需要外源性胰岛素治疗。
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1
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J Clin Oncol. 1993 Jan;11(1):152-4. doi: 10.1200/JCO.1993.11.1.152.
2
Effects of pregnancy and sex steroid administration on skeletal muscle metabolism in the rat.妊娠及给予性类固醇对大鼠骨骼肌代谢的影响。
Diabetes. 1981 Jul;30(7):545-50. doi: 10.2337/diab.30.7.545.
3
Progesterone and insulin-resistance: studies of progesterone action on glucose transport, lipogenesis and lipolysis in isolated fat cells of the female rat.孕酮与胰岛素抵抗：关于孕酮对雌性大鼠分离脂肪细胞中葡萄糖转运、脂肪生成及脂肪分解作用的研究
J Endocrinol. 1981 Mar;88(3):455-62. doi: 10.1677/joe.0.0880455.
4
Diabetes mellitus following pentamidine-induced hypoglycemia in humans.喷他脒诱发人类低血糖后发生的糖尿病
Diabetes. 1982 Jan;31(1):40-5.
5
HIV and the pancreas.人类免疫缺陷病毒与胰腺
Lancet. 1987 Nov 21;2(8569):1212-3.
6
Megestrol acetate-induced differentiation of 3T3-L1 adipocytes in vitro.醋酸甲地孕酮体外诱导3T3-L1脂肪细胞分化。
Semin Oncol. 1988 Apr;15(2 Suppl 1):76-8.
7
The effect of continuous subdermal levonorgestrel (Norplant) on carbohydrate metabolism.皮下持续植入左炔诺孕酮（诺普兰）对碳水化合物代谢的影响。
Am J Obstet Gynecol. 1992 Jan;166(1 Pt 1):15-9. doi: 10.1016/0002-9378(92)91819-v.
8
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Ann Intern Med. 1992 Jan 1;116(1):53-4. doi: 10.7326/0003-4819-116-1-53.
9
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Ann Intern Med. 1992 May 15;116(10):878. doi: 10.7326/0003-4819-116-10-878_1.
10
Usefulness of megestrol acetate in cancer cachexia and anorexia. A placebo-controlled study.
Am J Clin Oncol. 1992 Oct;15(5):436-40. doi: 10.1097/00000421-199210000-00008.
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