Sutter-Dub M T, Dazey B, Hamdan E, Vergnaud M T
J Endocrinol. 1981 Mar;88(3):455-62. doi: 10.1677/joe.0.0880455.
The effects of progesterone on isolated rat adipocytes were studied in vitro during various steps of glucose metabolism, transport, lipogenesis and lipolysis. Progesterone decreased the phosphorylation of glucose into glucose-6-phosphate as assessed by measuring the uptake of 2-deoxyglucose but it had no effect on transmembrane transport of glucose as determined by measuring the entry of 3-0-methylglucose into the cell. As glucose phosphorylation is a rate-limiting step of the pentose-phosphate pathway, these data could explain the inhibition of lipogenesis and the enhancement of lipolysis observed when progesterone is present in incubation medium. Progesterone might thus modulate a regulatory step of glucose metabolism and antagonize insulin action in the fat cell.
在体外研究了孕酮对分离的大鼠脂肪细胞在葡萄糖代谢、转运、脂肪生成和脂肪分解等各个步骤中的影响。通过测量2-脱氧葡萄糖的摄取来评估，孕酮降低了葡萄糖磷酸化为葡萄糖-6-磷酸的磷酸化过程，但通过测量3-O-甲基葡萄糖进入细胞来确定，它对葡萄糖的跨膜转运没有影响。由于葡萄糖磷酸化是戊糖磷酸途径的限速步骤，这些数据可以解释当孵育培养基中存在孕酮时观察到的脂肪生成抑制和脂肪分解增强现象。因此，孕酮可能调节葡萄糖代谢的一个调节步骤，并拮抗脂肪细胞中胰岛素的作用。
