Castagnola E, Davidson R N, Fiore P, Tasso L, Rossi G, Mangraviti S, Di Martino L, Scotti S, Cascio A, Pempinello R, Gradoni L, Giacchino R
Department of Infectious Diseases, Gaslini Children's Hospital, Genoa, Italy.
Trans R Soc Trop Med Hyg. 1996 May-Jun;90(3):317-8. doi: 10.1016/s0035-9203(96)90270-9.
The rapidity and efficacy of a short course of liposomal amphotericin B was evaluated in 29 children affected by visceral leishmaniasis (Leishmania infantum). Their overall health status was assessed using the prognostic inflammatory and nutritional index (PINI), and their haematological status by the reticulocyte count and haemoglobin blood levels. All these quantities were measured on day 0, and 3 and 10 d after starting therapy. A significant decrease of inflammatory signs, associated with an improved reticulocyte count, was recorded after 3 d of therapy. A significant increase of haemoglobin levels was also observed 10 d after the start of treatment. The early reduction of inflammatory signs and the improvement of bone marrow function in most patients confirmed the validity of amphotericin B therapy. The PINI score is helpful in assessing the severity of visceral leishmaniasis and the follow-up of its treatment.
对29名患内脏利什曼病（婴儿利什曼原虫）的儿童评估了短疗程脂质体两性霉素B的快速性和疗效。使用预后炎症和营养指数（PINI）评估他们的整体健康状况，通过网织红细胞计数和血红蛋白血水平评估他们的血液学状况。所有这些量均在第0天以及开始治疗后3天和10天进行测量。治疗3天后，记录到炎症体征显著减轻，同时网织红细胞计数有所改善。治疗开始10天后还观察到血红蛋白水平显著升高。大多数患者炎症体征的早期减轻和骨髓功能的改善证实了两性霉素B治疗的有效性。PINI评分有助于评估内脏利什曼病的严重程度及其治疗的随访情况。
