Mineura K, Sasajima T, Kowada M, Ogawa T, Hatazawa J, Uemura K
Neurosurgical Service, Akita University Hospital, Japan.
Eur J Cancer. 1996 Jun;32A(7):1257-60. doi: 10.1016/0959-8049(96)00026-3.
Non-invasive positron emission tomography (PET) was performed to identify changes in blood flow and metabolism, specific to early stages of tumour occurrence or recurrence. 2 patients with slowly progressive gliomas from early to late stages of tumour development were analysed by serial PET measurements of circulation and metabolism using 15O-gas and 18F-fluorodeoxyglucose. PET revealed a persistent depression of oxygen metabolism, as indicated by the regional oxygen extraction fraction or metabolic rate of oxygen, in the regions where tumours were later found. Abnormal blood flow and metabolism may precede the morphological changes detected by computed tomography (CT) in patients with gliomas.
采用非侵入性正电子发射断层扫描（PET）来识别肿瘤发生或复发早期阶段特有的血流和代谢变化。对2例肿瘤从早期发展到晚期的缓慢进展性胶质瘤患者，使用15O气体和18F-氟脱氧葡萄糖通过PET连续测量循环和代谢进行分析。PET显示，在后来发现肿瘤的区域，区域氧摄取分数或氧代谢率表明氧代谢持续降低。在胶质瘤患者中，异常的血流和代谢可能先于计算机断层扫描（CT）检测到的形态学变化。
