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PET联合氨基酸示踪剂对WHO二级胶质瘤的临床价值

The Clinical Value of PET with Amino Acid Tracers for Gliomas WHO Grade II.

作者信息

Smits Anja, Baumert Brigitta G

机构信息

Department of Neuroscience, Neurology, University Hospital, Uppsala University, 751 85 Uppsala, Sweden.

出版信息

Int J Mol Imaging. 2011;2011:372509. doi: 10.1155/2011/372509. Epub 2011 Apr 28.

DOI:10.1155/2011/372509
PMID:21603237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3094834/
Abstract

The clinical management of adults with low-grade gliomas (LGGs) remains a challenge. There is no curative treatment, and management of individual patients is a matter of deciding optimal timing as well as right treatment modality. In addition to conventional imaging techniques, positron emission tomography (PET) with amino acid tracers can facilitate diagnostic and therapeutic procedures. In this paper, the clinical applications of PET with amino acid tracers (11)C-methyl-L-methionine (MET) and (18)F-fluoro-ethyl-L-tyrosine (FET) for patients with LGG are summarized. We also discuss the value of PET for the long-term followup of this patient group. Monitoring metabolic activity by PET in individual patients during course of disease will provide insight in the biological behavior and evolution of these tumors. As such, spatial changes in tumor activity over time, including shifts of hot-spot regions within the tumor, may reflect intratumoral heterogeneity and correlate to clinical parameters.

摘要

成人低级别胶质瘤（LGGs）的临床管理仍然是一项挑战。目前尚无治愈性治疗方法，对个体患者的管理在于确定最佳时机以及选择正确的治疗方式。除了传统成像技术外，使用氨基酸示踪剂的正电子发射断层扫描（PET）有助于诊断和治疗程序。本文总结了使用氨基酸示踪剂（11）C-甲基-L-蛋氨酸（MET）和（18）F-氟乙基-L-酪氨酸（FET）的PET在LGG患者中的临床应用。我们还讨论了PET在该患者群体长期随访中的价值。在疾病过程中通过PET监测个体患者的代谢活性将有助于深入了解这些肿瘤的生物学行为和演变。因此，肿瘤活性随时间的空间变化，包括肿瘤内热点区域的转移，可能反映肿瘤内异质性并与临床参数相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756a/3094834/2319249bd149/IJMI2011-372509.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756a/3094834/f866b081352f/IJMI2011-372509.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756a/3094834/c5819f00c253/IJMI2011-372509.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756a/3094834/065cb99ef921/IJMI2011-372509.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756a/3094834/2319249bd149/IJMI2011-372509.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756a/3094834/f866b081352f/IJMI2011-372509.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756a/3094834/c5819f00c253/IJMI2011-372509.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756a/3094834/065cb99ef921/IJMI2011-372509.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756a/3094834/2319249bd149/IJMI2011-372509.004.jpg

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