[The effect of mitomycin C on filtration surgery of glaucoma with poor prognosis].

OBJECTIVE

To determine the anticicatrization effect of mytomycin C (MMC).

METHODS

We randomly divided 30 cases (40 eyes) into two groups: 21 eyes in MMC group and 19 eyes in control group. Intra-operatively, 0.4 mg/ml MMC was used in the trabeculectomy in MMC group, and no MMC was used in the control group. The post-operative follow-up periods ranged from 6 to 25 months (mean, 10.0 months).

RESULTS

The successful rate of the operation of MMC group was 90.4% and that of the control group, 26.3% (P < 0.0001). The rate of eyes with functional filtering blebs was 17/21 and that of the control group, 4/19 (P = 0.002). Macular edema occurred in 3 eyes of MMC group and none in the eyes in the control group. There were no corneal complication and leakage of the wound.

CONCLUSION

The results show that MMC can promote the formation of functional filtering bleb and elevate the successful rate of filtration surgery.