Xiang L, Zhang W, Hu Y
Ophthalmology Department, Beijing Friendship Hospital, Capital Medical University.
Zhonghua Yan Ke Za Zhi. 1996 Jan;32(1):56-9.
The study was designed to investigate the effects of cryotherapy on intraocular tissues in ocular penetrating injury, and an experimental study was made on rabbits.
The penetrating injury models in both eyes of 23 (46 eyes) pigmental rabbits were performed. Cryotherapy was applied after the operation in the left eye but not in the right eye (the control) of each animal. All the pupils of the eyes were dilated and examined by ophthalmoscope and B-scan at different time after the operation. Enucleations were performed at 2 weeks, 6 weeks and 3 months and the enucleated eyeballs were examined pathologically by light and electron microscopy. The synchronous fundus and pathological changes were evaluated and analyzed statistically (Pearson Chi-square test).
The intraocular reaction and proliferation in cryotreated group was much more severe than those in the control one (P = 0.027), especially in the vitreous (P = 0.016). The incidence of tractional retinal detachment in cryotreated group was higher than that in the control.
It is suggested that the prophylactic cryotherapy in the posterior penetrating ocular injury of rabbits increase intraocular proliferation.
本研究旨在探讨冷冻疗法对兔眼穿透伤眼内组织的影响，并进行实验研究。
对23只（46只眼）有色家兔双眼制作穿透伤模型。每只动物术后对左眼行冷冻疗法，右眼（对照）不行冷冻疗法。术后不同时间对所有眼的瞳孔进行散瞳，用检眼镜和B超检查。于术后2周、6周和3个月摘除眼球，对摘除的眼球进行光镜和电镜病理检查。对同步的眼底和病理变化进行评估并统计学分析（Pearson卡方检验）。
冷冻治疗组的眼内反应和增殖比对照组严重得多（P = 0.027），尤其是玻璃体（P = 0.016）。冷冻治疗组牵拉性视网膜脱离的发生率高于对照组。
提示兔眼后部穿透伤预防性冷冻疗法会增加眼内增殖。
