Wang F, Wu G, Cong M
Department of Ophthalmology, First Affiliated Hospital of Qiqihar Medical College.
Zhonghua Yan Ke Za Zhi. 1996 Jan;32(1):60-2.
The study was designed to approach the pathogenesis of myopia.
Haisaik chickens were used to establish the animal models of myopia and form deprivation method was applied. Monocular eyelids were sutured for form deprivation on the 5th day after chicken birth.
Form deprivation leads to myopic refractive abnormality (P < 0.001). The ocular anteroposterior axis (P < 0.005), transverse and vertical diameters lengthen (P < 0.05). In the mean time, obvious pathologic changes were found. The cartilaginous cell layer of the sclera became thicker, the numbers of chondrocytes and binucleate cells were greater, and the fibrous layer of the sclera was thinner.
Form deprivation is the main cause of the development of myopia.
本研究旨在探讨近视的发病机制。
选用海赛克鸡建立近视动物模型，采用形觉剥夺法。在鸡出生后第5天，单眼缝合眼睑以造成形觉剥夺。
形觉剥夺导致近视性屈光异常（P<0.001）。眼前后轴（P<0.005）、横径和垂直径延长（P<0.05）。同时，发现明显的病理变化。巩膜软骨细胞层增厚，软骨细胞和双核细胞数量增多，巩膜纤维层变薄。
形觉剥夺是近视发展的主要原因。
