Gottlieb M D, Joshi H B, Nickla D L
Biology Department, City College, City University of New York, NY 10031.
Curr Eye Res. 1990 Dec;9(12):1157-65. doi: 10.3109/02713689009003472.
The sclera in myopic regions of chick eyes was studied histologically and compared to the sclera in corresponding regions of normal fellow eyes. Chicks had been monocularly deprived of form vision in the nasal half of the retina from hatching. The fellow control eye and the temporal retina of the deprived eye had normal vision. With this treatment, the resulting form-deprivation myopia and eye enlargement are restricted to the retinal region that had been form deprived. We found that the cartilaginous sclera in the myopic nasal region exhibited several differences from that in the corresponding non-myopic region: it was thicker, its cell density was lower, and the number of chondrocytes and binucleate cells was higher. In contrast, the fibrous sclera was thinner. These changes suggest that form-deprivation myopia causes an increased production of extracellular matrix and an increased level of mitotic activity in the cartilaginous sclera. As expected, the non-myopic temporal regions of experimental and control eyes did not differ in any of these parameters. The findings of the present study suggest that the eye enlargement accompanying form-deprivation myopia is not the consequence of scleral stretching but of abnormal growth.
对雏鸡眼睛近视区域的巩膜进行了组织学研究，并与正常对侧眼相应区域的巩膜进行了比较。雏鸡自孵化起单眼剥夺视网膜鼻侧一半的形觉。对侧对照眼和剥夺眼的颞侧视网膜视力正常。通过这种处理，所导致的形觉剥夺性近视和眼球增大仅限于形觉被剥夺的视网膜区域。我们发现，近视鼻侧区域的软骨性巩膜与相应的非近视区域相比有几个差异：它更厚，细胞密度更低，软骨细胞和双核细胞的数量更多。相比之下，纤维性巩膜更薄。这些变化表明，形觉剥夺性近视会导致软骨性巩膜中细胞外基质的产生增加以及有丝分裂活性水平升高。正如预期的那样，实验眼和对照眼的非近视颞侧区域在这些参数上没有差异。本研究结果表明，形觉剥夺性近视伴随的眼球增大不是巩膜拉伸的结果，而是异常生长的结果。
