[4,4'-二甲氧基-5,6,5',6'-二亚甲基二氧基联苯-2,2'-二甲酸二甲酯（DDB）对白血病HL-60细胞分化的诱导作用]
[Inducing effect of dimethy-4, 4'-dimethoxy-5, 6,5',6-dimethylenedioxybipheny-2, 2'-dicarboxylate (DDB) on differentiation of leukemia HL-60 cells].
作者信息
Liu Z, Cui Q, Fu T
机构信息
Department of Pharmacology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
出版信息
Zhonghua Yi Xue Za Zhi. 1996 Mar;76(3):214-7.
OBJECTIVE
To study the effects of anti-hepatitis drug, DDB, on leukemia cell line HL-60.
METHOD
Cytobiological methods were used.
RESULT
DDB was inhibited the proliferation of HL-60 cells. About 50% of HL-60 cells treated with DDB (10(-4)mol/L) for 6 days exhibited NBT reduction, and phagocytosis activity was also enhanced by DDB (10(-4)mol/L) for 4 days. The HL-60 cells treated with DDB turned out to be mature granulocytes morphologically.
CONCLUSION
The activity of acid phosphatase in DDB-treated HL-60 cells was significantly increased. DDB can induce HL-60 cells to differentiate along granulocyte lineage.
目的
研究抗肝炎药物联苯双酯（DDB）对白血病细胞系HL-60的作用。
方法
采用细胞生物学方法。
结果
DDB可抑制HL-60细胞增殖。用DDB（10⁻⁴mol/L）处理HL-60细胞6天，约50%的细胞表现出硝基蓝四氮唑（NBT）还原能力，用DDB（10⁻⁴mol/L）处理4天可增强吞噬活性。经DDB处理的HL-60细胞在形态上转变为成熟粒细胞。
结论
DDB处理的HL-60细胞中酸性磷酸酶活性显著增加。DDB可诱导HL-60细胞沿粒细胞系分化。
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