4,4'-二甲氧基-5,6,5',6'-双亚甲二氧基联苯-2,2'-二甲酸二甲酯（DDB）对人肝癌细胞系表型的逆转作用
[Reversing effect of dimethyl-4,4'-dimethoxy-5,6,5'6'-dimethylenedioxybiphenyl-2,2'- dicarboxylate(DDB) on the phenotypes of human hepatocarcinoma cell line].
作者信息
Liu Z, Liu G, Zhang S
机构信息
Department II of Pharmacology, Chinese Academy of Medical Sciences, Beijing.
出版信息
Zhonghua Yi Xue Za Zhi. 1995 Nov;75(11):676-8, 710.
When human Bel-7402 hepatocarcinoma cell line grew in a medium containing 10(-4)M DDB, the secretion of alpha-fetoprotein (AFP) and the activity of gamma-glutamyl-transpeptidase (gamma-GT) were significantly lower than the control cells, whereas the albumin (ALB) secretion and the activity of tyrosine-alpha-ketoglutarate transaminase (TAT) were markedly increased. DDB at the concentration of 10(-4)M could significantly increase the content of cAMP in Bel-7402 cells, and also suppressed the expressions of oncogene c-myc and hepatocarcinoma marker AFP gene and enhanced the anti-oncogene p53 expression. The results of this paper suggest that DDB has some reversing effects on the phenotypes of human Bel-7402 hepatocarcinoma cell line.
当人Bel - 7402肝癌细胞系在含有10⁻⁴M DDB的培养基中生长时，甲胎蛋白（AFP）的分泌和γ-谷氨酰转肽酶（γ-GT）的活性显著低于对照细胞，而白蛋白（ALB）的分泌和酪氨酸-α-酮戊二酸转氨酶（TAT）的活性则明显增加。浓度为10⁻⁴M的DDB可显著增加Bel - 7402细胞中cAMP的含量，还可抑制癌基因c - myc和肝癌标志物AFP基因的表达，并增强抗癌基因p53的表达。本文结果提示DDB对人Bel - 7402肝癌细胞系的表型有一定的逆转作用。
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