Blancard A, Monges P, Lacarelle B, Denis J P, Bongrand M C, Ragon C H, Gouin F
Service de Santé Publique Faculté de Médecine, Marseille, France.
Pathol Biol (Paris). 1996 May;44(5):384-8.
The amphotericin B in glucose solution is the reference's treatment of the major systemic mycoses. Because of its bad tolerance, certain authors put forward others vehicules such as fat emulsions. The aim of our work has been to study the physico-chemical stability of two regeneration's methods; P1: direct regeneration. P2: regeneration of 50mg of Fungizone in 5 ml of glucose serum and laced with 45 ml of Ivelip 20% versus PR: 50 mg of Fungizone in 50 ml of glucose serum. Our results seem to show that the P1 is totally incompatible with a parenteral administration, because 23% of the granulometric population has a diameter superior to 5 microns. The solution P2 seems better even if the pH is different from PR and a light depot comes after reconstitution.
葡萄糖溶液中的两性霉素B是治疗主要全身性真菌病的参考药物。由于其耐受性差，一些作者提出了其他载体，如脂肪乳剂。我们工作的目的是研究两种复溶方法的物理化学稳定性；P1：直接复溶。P2：将50mg两性霉素B在5ml葡萄糖溶液中复溶，再加入45ml 20%的依维莫司乳剂，与PR对比：50mg两性霉素B在50ml葡萄糖溶液中复溶。我们的结果似乎表明，P1完全不适合肠胃外给药，因为23%的颗粒群体直径大于5微米。溶液P2似乎更好，即使其pH值与PR不同，复溶后会出现轻微的药物沉积。
