Chevalet P, Tiab M, Miegeville M, Milpied N, Harousseau J L, Moreau P
Service d'hématologie, CHU de Nantes, France.
Rev Med Interne. 1996;17(6):474-6. doi: 10.1016/0248-8663(96)86441-1.
The authors report three cases of fusarial infection in neutropenic patients with hematologic malignancies. The first patient was affected by a cutaneous extensive fusariosis. The second patient developed a fusarial lung infection during a multiple organ failure following allogenic bone marrow transplantation. The third patient who presented with refractory acute myelogenous leukemia, developed fusarial skin lesions, and died from pulmonary failure. The treatment of fusarial infection is disappointing and requires amphotericin B, in association with hematopoietic growth factors. The role of new agents, or combination chemotherapy remains to be determinated. The recovery of adequate neutrophil levels is the most important factor in the resolution of fusarial infection.
作者报告了3例血液系统恶性肿瘤中性粒细胞减少患者发生镰刀菌感染的病例。首例患者患有皮肤广泛性镰刀菌病。第二例患者在异基因骨髓移植后的多器官功能衰竭期间发生了镰刀菌肺部感染。第三例患者患有难治性急性髓系白血病，出现了镰刀菌皮肤病变，并死于呼吸衰竭。镰刀菌感染的治疗效果令人失望，需要使用两性霉素B并联合造血生长因子。新型药物或联合化疗的作用仍有待确定。恢复足够的中性粒细胞水平是解决镰刀菌感染的最重要因素。
