异基因干细胞移植后采用脂质体两性霉素B和特比萘芬成功挽救治疗播散性皮肤镰刀菌病
Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation.
作者信息
Neuburger S, Massenkeil G, Seibold M, Lutz C, Tamm I, le Coutre P, Graf B, Doerken B, Arnold R
机构信息
Department of Hematology and Oncology, Charité University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany.
出版信息
Transpl Infect Dis. 2008 Jul;10(4):290-3. doi: 10.1111/j.1399-3062.2007.00296.x. Epub 2008 Jan 14.
Fusarium infections are associated with high mortality after allogeneic stem cell transplantation. We report on successful treatment of a disseminated cutaneous Fusarium proliferatum infection using liposomal amphotericin B and terbinafine. In vitro susceptibility tests of antifungal drugs suggest that terbinafine is a potent additional antifungal drug for disseminated cutaneous fusariosis.
镰刀菌感染与异基因造血干细胞移植后的高死亡率相关。我们报告了一例使用脂质体两性霉素B和特比萘芬成功治疗播散性皮肤增殖镰刀菌感染的病例。抗真菌药物的体外药敏试验表明，特比萘芬是治疗播散性皮肤镰刀菌病的一种有效的附加抗真菌药物。
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