Rarey K E, Curtis L M
Department of Anatomy, College of Medicine, University of Florida, Gainesville, 32610, USA.
Otolaryngol Head Neck Surg. 1996 Jul;115(1):38-41. doi: 10.1016/S0194-5998(96)70133-X.
Glucocorticoid receptors were detected in the human inner ear. The highest concentration of glucocorticoid receptor protein was measured by enzyme-linked immunosorbent assay in the spiral ligament tissues; the lowest concentration of glucocorticoid receptors was measured in the macula of the saccule. The demonstration of the presence of glucocorticoid receptors in human Inner ear tissues provides a basis to consider the direct effects of glucocorticoid action on select inner ear cells, rather than assuming a systemic antiinflammatory or immunosuppressive effect during the therapeutic treatment of patients with given inner ear disorders.
在人类内耳中检测到了糖皮质激素受体。通过酶联免疫吸附测定法测得螺旋韧带组织中糖皮质激素受体蛋白的浓度最高；球囊斑中糖皮质激素受体的浓度最低。人类内耳组织中存在糖皮质激素受体的这一发现为考虑糖皮质激素对特定内耳细胞的直接作用提供了依据，而不是在治疗特定内耳疾病的患者时假定其具有全身抗炎或免疫抑制作用。
