Li Z, Li C
Institute of Tissue Transplantation & Immunology, Jinan University, Guangzhou, China.
Yan Ke Xue Bao. 1995 Sep;11(3):168-72.
To examine the effect of Tii treatment of cornea graft survival in a rabbit model.
Tii was administered orally after eccentrical corneal transplantation. Survival times were determined by biomicroscopy. Cytotoxic T lymphocytes (CTL) and delayed-type hypersensitivity (DTH) responses to donor alloantigens were assessed at day 16 after heterotopic corneal grafts.
Administration of Tii reduced the incidence and prolonged the graft survival time. Both CTL and DTH responses to donor alloantigens were severely depressed in hosts treated with Tii. However, combination of Tii and cyclosporine further enhanced the immunosuppressive effects described above.
Tii is a potent immunosuppressant with the ability to prolong allograft survival in the rabbit penetrating keratoplasty model and may have coordinative effects with CsA through different mechanisms. Further studies are necessary to define any potentially coordinative role in the prevention of allograft rejection in human keratoplasty.
在兔模型中研究Tii治疗对角膜移植存活的影响。
在角膜偏心移植术后口服Tii。通过生物显微镜检查确定存活时间。在异位角膜移植术后第16天评估对供体同种异体抗原的细胞毒性T淋巴细胞（CTL）和迟发型超敏反应（DTH）。
给予Tii可降低发生率并延长移植物存活时间。在用Tii治疗的宿主中，对供体同种异体抗原的CTL和DTH反应均严重受到抑制。然而，Tii和环孢素联合使用进一步增强了上述免疫抑制作用。
Tii是一种有效的免疫抑制剂，能够在兔穿透性角膜移植模型中延长同种异体移植物的存活时间，并且可能通过不同机制与环孢素A具有协同作用。有必要进行进一步研究以确定其在预防人类角膜移植中同种异体移植物排斥反应方面的任何潜在协同作用。
