棕色脂肪部分交感神经切除术或肾上腺髓质切除术对冷饲养大鼠儿茶酚胺代谢的影响。
Effects of partial sympathectomy of brown fat or of adrenomedullectomy on catecholamine metabolism in cold-reared rats.
作者信息
Bertin R, De Marco F, Portet R
机构信息
Laboratoire d'Adaptation Energétique à l'Environnement, Ecole Pratique des Hautes Etudes, Paris, France.
出版信息
Comp Biochem Physiol A Physiol. 1996 Jul;114(3):251-6. doi: 10.1016/0300-9629(95)02138-8.
PMID:8759147
Abstract
- The aim of this work was to study the effects of surgical denervation of the interscapular brown adipose tissue (IBAT) and of bilateral adrenal demedullation on cold adaptation of rats. 2) After sympathectomy in the 28 degree C rats, there were substantial decreases in the IBAT NE basal level and turnover rate but no modifications in the heart and adrenals. In the 16 degree C rats there were also decreases in the basal level and turnover rate of the IBAT NE but, in addition, significant increases in levels and turnover rates of NE in the heart and of epinephrine in the adrenals. 3) Bilateral adrenal demedullation led to increases in the NE basal level and turnover rate in the IBAT and the heart in the 16 degree C rats; no effects were observed in the 28 degree C rats. 4) It is concluded that in rats born and reared in a mild cold environment a compensatory stimulation of catecholamine production and turnover rate occurs in some organs after a partial sympathectomy of BAT or bilateral adrenal demedullation.
摘要
- 本研究旨在探讨肩胛间棕色脂肪组织（IBAT）手术去神经支配及双侧肾上腺髓质切除对大鼠冷适应的影响。2) 在28℃环境下进行交感神经切除术后，大鼠IBAT中去甲肾上腺素（NE）的基础水平和周转率显著降低，但心脏和肾上腺无变化。在16℃环境下的大鼠，IBAT中NE的基础水平和周转率也降低，此外，心脏中NE水平和周转率以及肾上腺中肾上腺素水平和周转率显著升高。3) 双侧肾上腺髓质切除导致16℃环境下大鼠的IBAT和心脏中NE基础水平和周转率升高；在28℃环境下的大鼠未观察到影响。4) 得出结论：在轻度寒冷环境中出生并饲养的大鼠，棕色脂肪组织部分交感神经切除或双侧肾上腺髓质切除后，某些器官会出现儿茶酚胺产生和周转率的代偿性刺激。
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