Fukui A, Yamaguchi S, Tamada Y, Miyawaki H, Shirakabe M, Baniya G, Tomoike H
First Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Cardiovasc Res. 1996 Jun;31(6):899-906.
Little is known as to whether an increase in coronary perfusion pressure can alter the right ventricular (RV) distensibility and the contractile function as it does in the case of the LV.
In eight isolated isovolumically contracting canine hearts, RV and LV volumes and coronary perfusion were independently controlled. Effects of an increase in coronary perfusion pressure (from 73 +/- 1 to 152 +/- 6 mmHg) on the end-diastolic and end-systolic pressure-volume relations in both RV and LV were assessed.
Following an increase in coronary perfusion, and at a similar volume of the ventricles, end-diastolic pressure was elevated by 2.8 +/- 0.8 mmHg in RV and 8.9 +/- 2.0 mmHg in LV (P < 0.01; RV vs LV), and the slope of RV end-systolic pressure-volume relation, Ees, increased by 11 +/- 6% (P < 0.05) and that of the LV Ees by 21 +/- 5% (P < 0.01). The percent change of RV pressure-volume area (PVA) was less than that in LV-PVA (26 +/- 9 vs 48 +/- 11%; P < 0.05).
Accordingly, increases in coronary perfusion pressure and/or flow decreased the RV distensibility and enhanced the RV contractile function, the extent of which, however, was less than that in the LV.
关于冠状动脉灌注压升高是否能像在左心室（LV）那样改变右心室（RV）的扩张性和收缩功能，目前所知甚少。
在8个离体等容收缩的犬心模型中，右心室和左心室的容积以及冠状动脉灌注被独立控制。评估冠状动脉灌注压升高（从73±1 mmHg升至152±6 mmHg）对右心室和左心室舒张末期和收缩末期压力-容积关系的影响。
冠状动脉灌注增加后，在心室容积相似的情况下，右心室舒张末期压力升高2.8±0.8 mmHg，左心室升高8.9±2.0 mmHg（P<0.01；右心室与左心室相比），右心室收缩末期压力-容积关系斜率Ees增加11±6%（P<0.05），左心室Ees增加21±5%（P<0.01）。右心室压力-容积面积（PVA）的变化百分比小于左心室PVA的变化百分比（26±9%对48±11%；P<0.05）。
因此，冠状动脉灌注压和/或血流量的增加降低了右心室的扩张性并增强了右心室的收缩功能，然而，其程度小于左心室。
