Aganović I, Jelcić J, Kozić-Rukavina B
Zavod za endokrinologiju, dijabetes i bolesti metabolizma Klinike za unutarnje bolesti, KBC Rebro, Zagreb.
Lijec Vjesn. 1996 Mar;118 Suppl 1:28-32.
Hyperandrogenemia may be the most common endocrinopathy in women, affecting up to 10% of all women and as many as 30% of certain subgroups. Women with polycystic ovary syndrome have a unique disorder of insulin action and are at increased risk to develop NIDDM. NIDDM in women with PCOS has earlier age of onset than it does in the general population. Insulin-induced receptor autophosphorylation is diminished in 50% of PCOS women. PCOS may be a disease of abnormal protein tyrosine kinase receptor signaling. IGF-I and IGF-II play an important role in regulating ovarian androgen production via receptors.
高雄激素血症可能是女性中最常见的内分泌病，影响高达10%的所有女性以及多达30%的特定亚组女性。多囊卵巢综合征女性存在独特的胰岛素作用紊乱，患非胰岛素依赖型糖尿病（NIDDM）的风险增加。多囊卵巢综合征女性的NIDDM发病年龄比普通人群更早。50%的多囊卵巢综合征女性中胰岛素诱导的受体自身磷酸化减少。多囊卵巢综合征可能是一种异常蛋白酪氨酸激酶受体信号传导的疾病。胰岛素样生长因子-I（IGF-I）和胰岛素样生长因子-II（IGF-II）通过受体在调节卵巢雄激素生成中起重要作用。
