Bhattacharyya A K, Lund V J
Department of Rhinology, Royal National Throat, Nose and Ear Hospital, London, UK.
J Laryngol Otol. 1996 Jul;110(7):665-7. doi: 10.1017/s0022215100134553.
The genetic aspects of choanal atresia have not been clearly defined though it is probably a multifactorial trait as in cleft lip and cleft palate. The appearance of the condition in both single and successive generations supports this contention. Choanal atresia can occur as an isolated anomaly, but is more commonly associated with one or more concomitant congenital anomalies. In this report two sisters both in their teens presented with unilateral choanal atresia as an isolated anomaly. Endoscopic trans-nasal repair of choanal atresia was performed in both of them as this offers excellent visualisation and access.
后鼻孔闭锁的遗传学因素尚未明确界定，不过它可能像唇腭裂一样是一种多因素性状。该病症在单代和连续几代人中出现均支持这一观点。后鼻孔闭锁可作为一种孤立的异常情况出现，但更常见的是与一种或多种并发的先天性异常相关。在本报告中，两名十几岁的姐妹均表现为单侧后鼻孔闭锁这一孤立异常。两人均接受了后鼻孔闭锁的鼻内镜经鼻修复术，因为该手术能提供极佳的视野和操作通道。
