Watemberg S, Landau O, Avrahami R
Department of Surgery B, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Israel.
Am J Gastroenterol. 1996 Aug;91(8):1494-8.
For more than 2 centuries, the nature and pathophysiology of pharyngoesophageal (Zenker's) diverticulum has been a matter of argument. The intrinsic or extrinsic forces and structures that might play a role in the development of this disorder have been repeatedly scrutinized, and still today the different theories of muscular incoordination and/or spasm, cricopharyngeal achalasia, gastroesophageal reflux, or neuromuscular abnormalities try to find their way as the final word regarding etiology remains to be told. Options for treatment follow a similar pattern although myotomy and diverticulopexy seem to have yielded the best results. In this review, historical and current data gathered from the world literature are compiled in an attempt to give a clear overview of the pathophysiology surrounding the genesis of Zenker's diverticulum and the clinical manifestations, diagnosis, and different alternatives for definite treatment of this disorder.
两个多世纪以来，咽食管（Zenker）憩室的性质和病理生理学一直存在争议。可能在这种疾病发展中起作用的内在或外在力量及结构已被反复研究，直至今日，关于肌肉不协调和/或痉挛、环咽肌失弛缓症、胃食管反流或神经肌肉异常的不同理论仍试图成为病因学的定论。治疗选择也遵循类似模式，尽管肌切开术和憩室固定术似乎产生了最佳效果。在这篇综述中，我们汇集了从世界文献中收集的历史和当前数据，试图清晰概述围绕Zenker憩室形成的病理生理学、临床表现、诊断以及该疾病明确治疗的不同选择。
