Boyd E J
Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.
Am J Gastroenterol. 1996 Aug;91(8):1539-43.
It has been reported that 30-72% of patients with duodenal ulcer disease also have esophagitis. However, many of these reports included patients who had severe or complicated ulcer disease, so that the high prevalence may reflect pyloric stenosis or gastric hyper-secretion. The objective of this study was to determine the prevalence of esophagitis in unselected patients with duodenal ulcer disease or ulcer-like dyspepsia.
A prospective study of endoscopic and histological esophagitis in consecutive patients with either duodenal ulcer disease or with ulcer-like dyspepsia.
Of 27 patients with duodenal ulcer disease, 33% had endoscopic esophagitis, 26% had histological esophagitis, and 48% had esophagitis by either criterion. Of 66 patients with ulcer-like dyspepsia, 35% had endoscopic esophagitis, 47% had histological esophagitis, and 62% had esophagitis by either criterion. Esophagitis was independent of patients' Helicobacter pylori status.
Esophagitis is common in patients with duodenal ulcer disease, and the prevalence is similar in patients with ulcer-like dyspepsia. In addition to causing heartburn, esophagitis may also be cause ulcer-like epigastric pain. Concomitant esophagitis may account for the persisting or recurring dyspepsia that has been reported in up to one-third of duodenal ulcer patients after successful eradication of H. pylori.
据报道，30%至72%的十二指肠溃疡病患者同时患有食管炎。然而，这些报告中的许多患者患有严重或复杂的溃疡病，因此高患病率可能反映了幽门狭窄或胃酸过度分泌。本研究的目的是确定未经选择的十二指肠溃疡病或溃疡样消化不良患者中食管炎的患病率。
对连续的十二指肠溃疡病患者或溃疡样消化不良患者进行内镜和组织学食管炎的前瞻性研究。
27例十二指肠溃疡病患者中，33%有内镜下食管炎，26%有组织学食管炎，48%根据任一标准患有食管炎。66例溃疡样消化不良患者中，35%有内镜下食管炎，47%有组织学食管炎，62%根据任一标准患有食管炎。食管炎与患者的幽门螺杆菌感染状况无关。
食管炎在十二指肠溃疡病患者中很常见，在溃疡样消化不良患者中的患病率相似。食管炎除了引起烧心外，还可能导致溃疡样上腹痛。合并食管炎可能是高达三分之一的十二指肠溃疡患者在成功根除幽门螺杆菌后仍持续或复发消化不良的原因。
