单链DNA结合蛋白增强了大肠杆菌中CTG三联体重复序列的稳定性。
Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli.
作者信息
Rosche W A, Jaworski A, Kang S, Kramer S F, Larson J E, Geidroc D P, Wells R D, Sinden R R
机构信息
Department of Biochemistry and Biophysics, Texas A&M University, Texas Medical Center, Houston 77030-3303, USA.
出版信息
J Bacteriol. 1996 Aug;178(16):5042-4. doi: 10.1128/jb.178.16.5042-5044.1996.
Abstract
The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded-DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.
摘要
在大肠杆菌中分析了CTG三联体重复序列的稳定性，以确定导致其遗传不稳定的过程。通过一种用于稳定性分析的生化检测方法，我们发现单链DNA结合蛋白的缺失会导致三联体重复序列内大缺失频率的增加。
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