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正常及噪声损伤的毛丝鼠耳蜗的三次畸变产物耳声发射

The cubic distortion product otoacoustic emissions from the normal and noise-damaged chinchilla cochlea.

作者信息

Hamernik R P, Ahroon W A, Lei S F

机构信息

Auditory Research Laboratories, State University of New York at Plattsburgh 12901, USA.

出版信息

J Acoust Soc Am. 1996 Aug;100(2 Pt 1):1003-12. doi: 10.1121/1.416285.

DOI:10.1121/1.416285
PMID:8759953
Abstract

A normative study of the cubic distortion product emissions from 104 monaural and binaural chinchillas was undertaken to establish criteria upon which noise exposed animals could be evaluated. From this normative group, 47 randomly selected chinchillas were exposed to various high level (150-, 155-, and 160-db peak SPL) impulse noises. Auditory evoked potentials and cubic distortion product otoacoustic emissions were measured on each animal pre- and post-exposure and related to the sensory cell populations 30 days post-exposure. Both group mean and individual animal data indicated that the distortion product emissions were more sensitive, frequency-specific indices of noise-induced cochlear effects than pure-tone threshold measures. This was particularly evident near the threshold for noise-induced damage to the outer hair cell system.

摘要

对104只单耳和双耳龙猫的三次谐波畸变产物发射进行了一项规范性研究,以建立可用于评估噪声暴露动物的标准。从这个规范性群体中,随机挑选了47只龙猫,使其暴露于各种高强度(150、155和160分贝峰值声压级)的脉冲噪声中。在暴露前后对每只动物测量听觉诱发电位和三次谐波畸变产物耳声发射,并将其与暴露后30天的感觉细胞群体相关联。群体平均值和个体动物数据均表明,与纯音阈值测量相比,畸变产物发射是噪声诱发耳蜗效应更敏感、频率特异性的指标。这在接近噪声诱发外毛细胞系统损伤的阈值时尤为明显。

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