Subramaniam M, Henselman L W, Spongr V, Henderson D, Powers N L
Department of Communicative Disorders and Sciences, State University of New York, Buffalo, USA.
Ear Hear. 1995 Aug;16(4):372-81. doi: 10.1097/00003446-199508000-00004.
The effect of high-frequency interrupted noise exposures on evoked potential (EP) thresholds, distortion-product otoacoustic emissions (DPOAEs), and status of the outer hair cells was studied with the aim of understanding the correspondence among the three measures. Animal subjects were exposed to an octave band noise centered at 4 kHz at 85 dB SPL for 6 hr/day for 10 days. EP and DPOAE recordings were made before the exposure and on days 1, 2, 4, 6, 8, and 10 of exposure. A final set of measurements were made 5 days after the last exposure, following which the animals were sacrificed and their cochleas were examined using scanning electron microscopy. Both EPs and DPOAEs showed a worsening of auditory function after the first exposure and then showed a progressive recovery toward baseline. However, there was no consistent relationship between changes in EP thresholds and changes in DPOAEs nor were there any systematic changes in outer hair cells that corresponded with the changes in DPOAEs. Furthermore, EP thresholds often revealed considerable deficits in function while DPOAEs were normal.
为了了解三种测量方法之间的对应关系，研究了高频间断噪声暴露对诱发电位（EP）阈值、畸变产物耳声发射（DPOAE）以及外毛细胞状态的影响。动物实验对象每天暴露于中心频率为4kHz、声压级为85dB SPL的倍频程带噪声中，持续6小时，共10天。在暴露前以及暴露的第1、2、4、6、8和10天进行EP和DPOAE记录。在最后一次暴露后5天进行最后一组测量，之后处死动物并使用扫描电子显微镜检查它们的耳蜗。EP和DPOAE在首次暴露后均显示听觉功能恶化，然后逐渐恢复至基线水平。然而，EP阈值的变化与DPOAE的变化之间没有一致的关系，外毛细胞也没有与DPOAE变化相对应的系统性变化。此外，EP阈值常常显示出明显的功能缺陷，而DPOAE则正常。
