Robertson D M, Campbell R J
Mod Probl Ophthalmol. 1977;18:156-9.
Of 726 eyes consecutively enucleated at the Mayo Clinic from 1954 through 1974, 41 contained retinoblastoma. In no instance was unsuspected retinoblastoma identified, nor could retinoblastoma be confirmed pathologically in an additional eight eyes in which retinoblastoma was considered in the differential diagnosis. In each of our eight misdiagnosed cases, the eyes were already blind and were cosmetically defective. The frequency of clinical misdiagnosis of retinoblastoma is high in part because it must be considered in every case of leukokoria. Although every effort was made to arrive at an accurate clinical diagnosis, the clinical misdiagnosis of retinoblastoma in a blind eye is of far less serious consequence than the clinical misdiagnosis of a tumor in a seeing eye.
在1954年至1974年期间于梅奥诊所连续摘除的726只眼中，有41只患有视网膜母细胞瘤。未发现意外的视网膜母细胞瘤病例，在另外8只鉴别诊断中考虑为视网膜母细胞瘤的眼中，也无法通过病理证实为视网膜母细胞瘤。在我们的8例误诊病例中，每只眼睛都已失明且外观有缺陷。视网膜母细胞瘤临床误诊的发生率较高，部分原因是在每例白瞳症病例中都必须考虑到该病。尽管已尽一切努力做出准确的临床诊断，但失明眼中视网膜母细胞瘤的临床误诊后果远不如有视力眼中肿瘤的临床误诊严重。
