控释型茶碱可抑制哮喘患者清晨气道阻塞和高反应性。

Controlled-release theophylline inhibits early morning airway obstruction and hyperresponsiveness in asthmatic subjects.

作者信息

Crescioli S, Dal Carobbo A, Maestrelli P, Boschetto P, Santagada T, Steinijans V W, Hurst T S, Parise G, Fabbri L M

机构信息

Institute of Occupational Medicine, St. Antonio Hospital, University of Padua, Italy.

出版信息

Ann Allergy Asthma Immunol. 1996 Aug;77(2):106-10. doi: 10.1016/s1081-1206(10)63495-3.

DOI:10.1016/s1081-1206(10)63495-3

PMID:8760775

Abstract

BACKGROUND

Nocturnal asthma reflects the severity of the disease, and thus its pharmacologic prevention represents one on the main goals of asthma management.

SUBJECTS AND METHODS

To determine whether controlled-release theophylline inhibits the development of airway obstruction and/or airway hyperresponsiveness early in the morning, we examined 18 subjects reporting recurrent nocturnal asthma. In each subject, after five days' treatment with an 8 PM increasing dose of oral controlled-release theophylline, up to 10 +/- 1 mg/kg or placebo the night before the study day, we measured serum theophylline, FEV1 and PC20FEV1 at 6 AM, 2 PM and 10 PM.

RESULTS

At 6 AM, both FEV1 and PC20FEV1 were significantly higher on theophylline than on placebo (3.52 +/- 0.22 versus 3.17 +/- 0.25 L; P < .005 and 2.76 divided by 3.61 versus 1.55 divided by 3.73 mg/mL; P < .05, respectively). At 2 PM and 10 PM FEV1, but not PC20FEV1, was higher on theophylline than on placebo (3.73 +/- 0.21 versus 3.54 +/- 0.25 L; P < .05 and 3.40 +/- 0.22 versus 3.24 +/- 0.24 L; P < .05). Serum theophylline was 12.8 +/- 1.1 micrograms/ml, 8.9 +/- 0.77 and 9.5 +/- 0.85 at 6 AM, 2 PM and 10 PM, respectively.

CONCLUSIONS

We conclude that an evening dose of controlled-release theophyl line inhibits early morning airway obstruction and hyperresponsiveness, and that it may be helpful in the prevention of nocturnal asthma.

摘要

背景

夜间哮喘反映了疾病的严重程度，因此其药物预防是哮喘管理的主要目标之一。

对象与方法

为了确定控释茶碱是否能在清晨抑制气道阻塞和/或气道高反应性的发展，我们对18名报告有复发性夜间哮喘的受试者进行了研究。在每位受试者于研究日前一晚8点开始口服递增剂量的控释茶碱（最高达10±1mg/kg）或安慰剂治疗5天后，我们在上午6点、下午2点和晚上10点测量血清茶碱、第一秒用力呼气容积（FEV1）和使FEV1下降20%所需的激发剂量（PC20FEV1）。

结果

上午6点时，使用茶碱时的FEV1和PC20FEV1均显著高于使用安慰剂时（分别为3.52±0.22L对3.17±0.25L；P<0.005；以及2.76÷3.61对1.55÷3.73mg/mL；P<0.05）。下午2点和晚上10点时，使用茶碱时的FEV1高于使用安慰剂时（分别为3.73±0.21L对3.54±0.25L；P<0.05；以及3.40±0.22L对3.24±0.24L；P<0.05），但PC20FEV1无差异。上午6点、下午2点和晚上10点时血清茶碱浓度分别为12.8±1.1μg/ml、8.9±0.77μg/ml和9.5±0.85μg/ml。