The molecular jury: deciding whether immature thymocytes should live or die.
作者信息
Vukmanović S
机构信息
Department of Pathology, NYU Medical Center, New York 10016, USA.
出版信息
J Exp Med. 1996 Aug 1;184(2):305-9. doi: 10.1084/jem.184.2.305.
Abstract
摘要
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The molecular jury: deciding whether immature thymocytes should live or die.分子评审团：决定未成熟胸腺细胞的生死
J Exp Med. 1996 Aug 1;184(2):305-9. doi: 10.1084/jem.184.2.305.
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Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes.血管细胞黏附分子-1（VCAM-1）和细胞间黏附分子-1（ICAM-1）在阳性选择过程中与被选择胸腺细胞的存活一起提供共刺激。
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Deadbeat neighbors influence thymocyte lineage commitment.赖账的邻居会影响胸腺细胞谱系定向分化。
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Fas modulates both positive and negative selection of thymocytes.Fas调节胸腺细胞的阳性和阴性选择。
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Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.未成熟胸腺细胞上表达的CD4和CD8的结合可诱导细胞内酪氨酸磷酸化途径的激活。
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本文引用的文献
1
Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes.B7和细胞间黏附分子-1在胸腺细胞阴性选择中的不同作用。
J Exp Med. 1996 Aug 1;184(2):531-7. doi: 10.1084/jem.184.2.531.
2
Bone marrow-derived cells fail to induce positive selection in thymus reaggregation cultures.骨髓来源的细胞在胸腺重聚集培养物中无法诱导阳性选择。
J Exp Med. 1996 Mar 1;183(3):1235-40. doi: 10.1084/jem.183.3.1235.
3
Mature T cell reactivity altered by peptide agonist that induces positive selection.肽激动剂诱导阳性选择改变成熟T细胞反应性。
J Exp Med. 1996 Mar 1;183(3):1093-104. doi: 10.1084/jem.183.3.1093.
4
Thymus epithelium induces tissue-specific tolerance.胸腺上皮诱导组织特异性耐受。
J Exp Med. 1993 Apr 1;177(4):1153-64. doi: 10.1084/jem.177.4.1153.
5
Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro.髓质胸腺上皮细胞在体内和体外均表达CTLA4的配体。
J Immunol. 1993 Sep 1;151(5):2453-61.
6
Positive selection of T lymphocytes on fibroblasts.T淋巴细胞在成纤维细胞上的阳性选择。
Nature. 1993 Aug 12;364(6438):642-5. doi: 10.1038/364642a0.
7
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.通过T细胞受体诱导的细胞凋亡对CD4+CD8+胸腺细胞进行阴性选择需要共刺激信号，该信号可由CD28提供。
J Exp Med. 1994 Feb 1;179(2):709-13. doi: 10.1084/jem.179.2.709.
8
T cell receptor antagonist peptides induce positive selection.T细胞受体拮抗剂肽诱导阳性选择。
Cell. 1994 Jan 14;76(1):17-27. doi: 10.1016/0092-8674(94)90169-4.
9
The specificity of positive selection: MHC and peptides.
Immunol Rev. 1993 Oct;135:51-66. doi: 10.1111/j.1600-065x.1993.tb00643.x.
10
Positive selection of TcR alpha beta thymocytes: is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein?T细胞受体αβ胸腺细胞的阳性选择：皮质胸腺上皮细胞是主要组织相容性复合体蛋白呈递过程中的必需参与者吗？
Immunol Rev. 1993 Oct;135:133-55. doi: 10.1111/j.1600-065x.1993.tb00647.x.
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