Boisier P, Rabarijaona L, Piollet M, Roux J F, Zeller H G
Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Epidemiol Infect. 1996 Aug;117(1):133-7. doi: 10.1017/s0950268800001229.
To describe the features of hepatitis B virus (HBV) infection in Madagascar, a randomized sero-epidemiological survey was undertaken in the general population > or = 1 year old of two provinces which represents 45% of the total population. In the 921 sera tested, the prevalence of HBV markers was 20.5% for HBsAg, 38.2% for anti-HBc and 6.9% for HBeAg. HBsAg and anti-HBc prevalence rates were significantly higher in males. A large difference in HBsAg prevalence was observed between urban (5.3%) and rural areas (26.0%). The same contrast in prevalence was noticed for the other HBV markers. In rural areas, HBV infection was more frequently acquired early in infancy, which suggests predominantly perinatal or postnatal transmission. The presence of HBV markers was not significantly associated with a history of blood transfusion, surgery or parenteral injection. High infectivity carriers represented 5.3% and the overall frequency of chronic carriers was 10.4%. These results place Madagascar among areas of high endemicity.
为描述马达加斯加乙型肝炎病毒（HBV）感染的特征，在占全国总人口45%的两个省份中，针对1岁及以上普通人群开展了一项随机血清流行病学调查。在检测的921份血清中，HBsAg的HBV标志物流行率为20.5%，抗-HBc为38.2%，HBeAg为6.9%。男性的HBsAg和抗-HBc流行率显著更高。城市地区（5.3%）和农村地区（26.0%）的HBsAg流行率存在很大差异。其他HBV标志物的流行率也呈现同样的差异。在农村地区，HBV感染更常在婴儿早期获得，这表明主要是围产期或产后传播。HBV标志物的存在与输血、手术或注射史无显著关联。高传染性携带者占5.3%，慢性携带者的总体频率为10.4%。这些结果表明马达加斯加属于高流行地区。
