Perrin C, Castanet J, Lacour J P, Michiels J F
Service d'Anatomie pathologique, Universitaire de Nice.
Ann Dermatol Venereol. 1996;123(2):114-7.
Acquired elastolysis of the papillary dermis simulating pseudoxanthoma elasticum and white papulosis of the neck are two skin diseases with clearly limited borders. The two entities can be distinguished clinically when papulae converge into yellowish-white patches and histologically by complete absence of the elastic network in the papillary dermis without thickening of the collagen network in the superficial and mid dermis.
We observed a patient with the clinical and histological criteria for acquired elastolysis of the papillary dermis. Histological examination showed a thick collagen network as described in white papulosis of the neck.
This case clearly demonstrates the histological continuum between these two entities. A review of the literature also provided evidence of borderline forms, leading us to propose grouping them together. Elastolysis of the papillary dermis would appear to be a relatively specific histological sign differentiating white papulosis of the neck, in a general sense, and acquired elastosis of the mid dermis. Two factors could explain the rare observations of acquired elastosis of the mid dermis in patients with acquired elastosis of the papillary derma: use of the Verhoeff Van Gieson stain without an internal control and imprecise localization of the biopsy.
后天性乳头真皮弹力纤维松解症，类似弹性假黄瘤，以及颈部白色丘疹病，是两种边界明显局限的皮肤病。当丘疹融合成黄白色斑块时，这两种疾病在临床上可以区分，在组织学上，乳头真皮中完全没有弹性网络，且浅真皮和中真皮中的胶原网络没有增厚。
我们观察了一名符合后天性乳头真皮弹力纤维松解症临床和组织学标准的患者。组织学检查显示胶原网络增厚，如颈部白色丘疹病中所述。
该病例清楚地证明了这两种疾病在组织学上的连续性。对文献的回顾也提供了交界性病例的证据，促使我们建议将它们归为一组。乳头真皮弹力纤维松解症似乎是一个相对特异的组织学标志，从总体上区分颈部白色丘疹病和后天性中真皮弹力纤维增生症。有两个因素可以解释在后天性乳头真皮弹力纤维增生症患者中后天性中真皮弹力纤维增生症的罕见观察结果：使用无内部对照的Verhoeff Van Gieson染色以及活检部位定位不准确。
