Nicholls J, Saunders N
Dept of Pharmacology, Biozentrum, University of Basel, Switzerland.
Trends Neurosci. 1996 Jun;19(6):229-34. doi: 10.1016/0166-2236(96)10021-7.
In this review we describe the growth of regenerating fibres through lesions in immature mammalian spinal cord. In newborn opossums and foetal rats, repair occurs rapidly and reliably without antibodies, implants or bridges of undamaged spinal cord. In the neonatal opossum one can compare recovery from lesions made to the CNS at various stages of development in the animal and in culture. As the CNS matures, the capacity for regeneration ceases abruptly. In particular, the extracellular matrix and molecules associated with glia have been shown to play a role in promoting and inhibiting regeneration. Major problems concern the precision with which regenerating axons become reconnected to their targets, and the specificity needed for recovery of function.
在本综述中，我们描述了未成熟哺乳动物脊髓损伤后再生纤维的生长情况。在新生负鼠和胎鼠中，修复迅速且可靠地发生，无需抗体、植入物或未受损脊髓桥接。在新生负鼠中，可以比较动物在不同发育阶段以及在培养环境中对中枢神经系统造成损伤后的恢复情况。随着中枢神经系统成熟，再生能力会突然终止。特别是，已证明细胞外基质和与神经胶质相关的分子在促进和抑制再生方面发挥作用。主要问题涉及再生轴突重新连接到其靶标的精确程度，以及功能恢复所需的特异性。
