Zhao L, Lu D, Xu Q
Department of Pathology, Xuan Wu Hospital, Beijing.
Zhonghua Bing Li Xue Za Zhi. 1996 Feb;25(1):10-2.
Immunohistochemical staining of 5 gliosarcomas was performed. Neoplastic glial component stained positive by GFAP. Endothelial cells lining the lumina of glomeruloid vascular structures stained positively with both UEA-1 and FVIII/RAg antibodies. Mesenchymal cells of sarcomatous areas stained positively with SMSA antibody and presence of PDGFR. The staining results demonstrate that the sarcomatous component of gliosarcoma is of smooth muscle origin and suggest that the vascular smooth muscle hyperplasia is related to PDGF.
对5例胶质肉瘤进行了免疫组织化学染色。肿瘤性胶质成分GFAP染色呈阳性。肾小球样血管结构管腔内衬的内皮细胞UEA-1和FVIII/RAg抗体染色均呈阳性。肉瘤区域的间充质细胞SMSA抗体染色呈阳性且存在血小板衍生生长因子受体（PDGFR）。染色结果表明，胶质肉瘤的肉瘤成分起源于平滑肌，提示血管平滑肌增生与血小板衍生生长因子（PDGF）有关。
