Dong J C, Xu L N
Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
Yao Xue Xue Bao. 1996;31(1):6-9.
Acetylsalvianolic acid A (ASAA) is a semisynthetic analogue of salvianolic acid A isolated from Danshen (Salvia miltiorrhiza Bunge). A rat middle cerebral artery thrombosis model was made by adding FeCl3 to the surface of the right middle cerebral artery (MCA). Using this model, the protective effects of ASAA on focal cerebral ischemic injury were studied. The neurologic status of each rat was carefully evaluated at 4, 8 and 24 h after surgery. The cerebral infarction and the morphological changes of brain tissue were examined. Pretreatment with ASAA 50 or 100 mg.kg-1 iv was shown to significantly reduce the cerebral infarction and attenuate neurological deficits. The degree of inhibition of cerebral infarction were 46.5% (P < 0.05) and 87.4% (P < 0.01), respectively. In pathological examination, pretreatment with ASAA 100 mg.kg-1 iv, there was no thrombosis or only a little thrombosis in MCA. The extent of tissue ischemia was much less than that of control. These results indicate that the beneficial effects of ASAA on focal cerebral ischemic rats subjected to middle cerebral artery thrombosis may be related to its antithrombotic effect.
乙酰丹参酸A（ASAA）是从丹参（Salvia miltiorrhiza Bunge）中分离得到的丹参酸A的半合成类似物。通过在大鼠右侧大脑中动脉（MCA）表面添加FeCl3建立大鼠大脑中动脉血栓形成模型。利用该模型研究了ASAA对局灶性脑缺血损伤的保护作用。在术后4、8和24小时仔细评估每只大鼠的神经功能状态。检查脑梗死情况及脑组织的形态学变化。静脉注射50或100mg·kg-1的ASAA预处理显示可显著减少脑梗死并减轻神经功能缺损。脑梗死的抑制程度分别为46.5%（P<0.05）和87.4%（P<0.01）。病理检查显示，静脉注射100mg·kg-1的ASAA预处理后，大脑中动脉无血栓形成或仅有少量血栓形成。组织缺血程度远低于对照组。这些结果表明，ASAA对大脑中动脉血栓形成的局灶性脑缺血大鼠的有益作用可能与其抗血栓作用有关。
