Adams James David, Wang Rubin, Yang Jun, Lien Eric Jungchi
Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089-9121, USA.
Chin Med. 2006 Nov 23;1:3. doi: 10.1186/1749-8546-1-3.
Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) and its preparations are currently used in China to treat patients suffering from heart attack, angina pectoris, stroke and some other conditions. The use of S. miltiorrhiza has been increasing in the management of stroke. Pharmacological examinations showed that the plant and its active ingredients, tanshinones and salvianolic acids, have anticoagulant, vasodilatory, increased blood flow, anti-inflammatory, free radical scavenging, mitochondrial protective and other activities. This review discusses the pharmacology, medicinal chemistry and clinical studies published, especially in China, for danshen and tanshinone preparations. Clinical examinations are evaluated in terms of S. miltiorrhiza preparation, dose, double blinding, control, clinical assessments of outcomes and other parameters. Meta-analyses of S. miltiorrhiza are also discussed.
丹参（唇形科、薄荷科），又称丹參，是一种一年生鼠尾草，主要生长在中国及周边国家。其生药（干燥根）及其制剂目前在中国用于治疗心脏病发作、心绞痛、中风和其他一些病症。丹参在中风治疗中的应用一直在增加。药理学研究表明，该植物及其活性成分丹参酮和丹酚酸具有抗凝、血管舒张、增加血流量、抗炎、清除自由基、保护线粒体等活性。本综述讨论了已发表的关于丹参和丹参酮制剂的药理学、药物化学和临床研究，特别是在中国发表的研究。根据丹参制剂、剂量、双盲、对照、结局的临床评估和其他参数对临床研究进行了评估。还讨论了丹参的荟萃分析。
