Li X, Dai X, He A
Cancer Research Institute, China Medical University, Shenyang.
Zhonghua Jie He He Hu Xi Za Zhi. 1995 Oct;18(5):285-6, 317.
The sputum specimens from 116 healthy persons and 216 cases of benign and malignant lung diseases were detected for T antigen using a strip test by enzyme galactose oxidase-Schiff sequence. The result shows that 165 cases of the 182 patients with lung cancer, confirmed by cytology and histology, had positive results, whereas 22/116 (19.0%) of healthy controls were positive. So the sensitivity was 90.7% and the specificity was 81.0%. In 28 cases of patients whose cytology of sputa showed various degrees of dysplasia, 21 were found T antigen positive, of which 15 patients were identified to be lung cancer in the follow-up study. In addition, three cases of early lung cancer in this study were also positive, suggesting that T antigen was expressed at an earlier stage in the malignant process. The study has indicated that T antigen test of sputum is a sensitive method for the diagnosis of lung cancer. It may also be a promising approach for the massive screening of lung cancer in terms of its rapidity, economy and simplicity.
采用酶促半乳糖氧化酶-席夫序列试纸条法对116名健康人和216例良恶性肺部疾病患者的痰液标本进行T抗原检测。结果显示，经细胞学和组织学确诊的182例肺癌患者中，165例结果呈阳性，而116名健康对照者中有22例（19.0%）呈阳性。因此，敏感性为90.7%，特异性为81.0%。在28例痰液细胞学显示不同程度发育异常的患者中，21例T抗原呈阳性，其中15例患者在随访研究中被确诊为肺癌。此外，本研究中的3例早期肺癌也呈阳性，表明T抗原在恶性病变过程中更早表达。该研究表明，痰液T抗原检测是诊断肺癌的一种敏感方法。就其快速、经济和简便性而言，它也可能是大规模筛查肺癌的一种有前景的方法。
