Wang H, Sun B
Department of Respiratory Disease, Xijing Hospital, 4th Military Medical University, Xian.
Zhonghua Jie He He Hu Xi Za Zhi. 1995 Oct;18(5):306-8, 319.
To study the influence of corticosteroid and beta 2-agonist on eosinophil and T lymphocyte functioning state in the asthmatics, we measured the serum ECP sIL-2R levels and airway reactivity before and after 6-week treatment with beclometasone and terbutalin. The result revealed that after inhalation of steroid, the serum ECP sIL-2R levels decreased, whereas the lung function improved and MCH-PC20 values increased. It suggested that steroid could inhibit activation of eosinophil and T lymphocyte as well as show the effect of anti-inflammation and reducing AHR.
为研究皮质类固醇和β2激动剂对哮喘患者嗜酸性粒细胞和T淋巴细胞功能状态的影响，我们在用倍氯米松和特布他林治疗6周前后，测量了血清嗜酸性粒细胞阳离子蛋白（ECP）、可溶性白细胞介素2受体（sIL-2R）水平及气道反应性。结果显示，吸入类固醇后，血清ECP、sIL-2R水平降低，肺功能改善，组胺激发试验浓度反应曲线斜率（MCH-PC20）值增加。这表明类固醇可抑制嗜酸性粒细胞和T淋巴细胞的活化，具有抗炎及降低气道高反应性的作用。
