Zhang Y, Qi G, Lui J
People's Hospital, Beijing Medical University.
Zhonghua Wai Ke Za Zhi. 1995 Dec;33(12):754-6.
The authors investigated the relationship between portal-systemic shunting and portal pressure in 16 CCl4-induced cirrhotic wistar rats by 99mTc-MIBI photography of heart and liver. Based on radio-counts taken at 30 minutes after 99mTc-MIBI was given per rectum 8 rats or medial clonic vein 8 rats, heart radio-counts/liver radio-counts (H/L) and portal-systemic shunting index (SI) were recorded. It was shown that 1. H/L and SI of the two cirrhotic groups were greater than those of normals (P < 0.001); 2. H/L in cirrhotic rats by rectum 99mTc-MIBI administration was more closely related to free portal pressure (FPP, r = 0.83, P < 0.01) than in those by venous route (r = 0.74, P < 0.05) and its regressive formation FPP (kPa) = 0. 24 + 4.06 (H/L) was deduced and used to calculate portal pressure of cirrhotic rats. The very good relationship between the calculated and measured portal venous pressure was shown in a group of 12 cirrhotic rats (r = 0.85, P < 0.01). These findings suggested that the rectum administration of 99mTc-MIBI may be a useful method in calculating portal pressure and portal-systemic shunting in portal hypertensive patients.
作者通过对16只四氯化碳诱导的肝硬化Wistar大鼠进行心脏和肝脏的99mTc-MIBI显像，研究了门体分流与门静脉压力之间的关系。根据经直肠给予99mTc-MIBI 30分钟后或经肠系膜静脉给予99mTc-MIBI 30分钟后获得的放射性计数，分别对8只大鼠和8只大鼠进行记录，计算心脏放射性计数/肝脏放射性计数（H/L）和门体分流指数（SI）。结果表明：1. 两个肝硬化组的H/L和SI均高于正常组（P<0.001）；2. 经直肠给予99mTc-MIBI的肝硬化大鼠的H/L与自由门静脉压力（FPP，r = 0.83，P<0.01）的相关性比经静脉途径给药的大鼠（r = 0.74，P<0.05）更强，并推导出门体分流与FPP的回归方程FPP（kPa）= 0.24 + 4.06（H/L），用于计算肝硬化大鼠的门静脉压力。在一组12只肝硬化大鼠中，计算得到的门静脉压力与测量得到的门静脉压力之间显示出非常好的相关性（r = 0.85，P<0.01）。这些发现表明，经直肠给予99mTc-MIBI可能是一种计算门静脉高压患者门静脉压力和门体分流的有用方法。
