Fu D, Zhang Y, Wang Z
Huashan Hospital, Shanghai Medical University.
Zhonghua Wai Ke Za Zhi. 1995 Dec;33(12):757-9.
The contractile effect of erythromycin on gallbladder has not been fully understood. This effect was investigated in the isolated gallbladder of golden hamster gallstone model and in human by ultrasonography. Erythromycicn induced concentration-dependent contraction of gallbladder in 28 hamsters with normal diet and in 13 with gallstone diet. In those two groups the maximal contractile effect and the half maximal effective concentration were similar (P > 0.05). In clinical study, the fasting volume and residual volume were significantly diminished in 23 volunteers and 15 with cholecystolithiasis and the ejection fraction and the constant emptying rate increased (P < 0.05). Erythromycin also modulated the hypomotility of gallbladder in gallstone patients, hence could be used in gallbladder hypomotility cases.
红霉素对胆囊的收缩作用尚未完全明确。本研究通过超声检查在金黄仓鼠胆结石模型的离体胆囊以及人体中对这一作用进行了探究。红霉素可引起28只正常饮食仓鼠和13只胆结石饮食仓鼠的胆囊产生浓度依赖性收缩。在这两组中，最大收缩效应和半数最大效应浓度相似（P>0.05）。在临床研究中，23名志愿者和15名胆囊结石患者的空腹容积和残余容积显著减小，射血分数和恒定排空率增加（P<0.05）。红霉素还可调节胆结石患者胆囊的运动功能减退，因此可用于胆囊运动功能减退的病例。
