Portincasa P, DiCiaula A, Palmieri V, Velardi A, Van Berge-Henegouwen G P, Palasciano G
Dipartimento di Medicina Interna e del Lavoro (Di.M.I.L.), Università di Bari, Italy.
Ital J Gastroenterol. 1996 Feb-Mar;28(2):111-3.
Fasting and postprandial gallbladder volumes have been measured by sonography both in healthy subjects and gallstone patients ingesting: (a) tauroursodeoxycholic acid; (b) ursodeoxycholic acid; (c) placebo. Each bile salt was given at a dose of 10 mg kg-1. Sonography was repeated in gallstone patients fed tauroursodeoxycholic acid or ursodeoxycholic acid (10 mg kg-1 day-1) for 1 month. Gallstone patients had gallbladder stasis (increase in fasting and residual volumes) and decreased postprandial emptying. Acute ingestion of tauroursodeoxycholic acid or ursodeoxycholic acid did not modify postprandial gallbladder emptying in both groups of subjects. After one month's therapy with tauroursodeoxycholic acid or ursodeoxycholic acid, fasting gallbladder volume further increased in gallstone patients, although gallbladder emptying remained unchanged. Thus, therapeutic doses of tauroursodeoxycholic acid or ursodeoxycholic acid do not acutely modify postprandial gallbladder emptying in either healthy subjects or gallstone patients. Chronic treatment with either bile salts results in an increase in fasting gallbladder volume without interfering with the extent of postprandial gallbladder emptying.
(a) 牛磺熊去氧胆酸；(b) 熊去氧胆酸；(c) 安慰剂。每种胆盐的给药剂量均为10 mg/kg。对服用牛磺熊去氧胆酸或熊去氧胆酸（10 mg/kg/天）1个月的胆结石患者重复进行超声检查。胆结石患者存在胆囊淤滞（空腹和残余体积增加）且餐后排空减少。急性摄入牛磺熊去氧胆酸或熊去氧胆酸对两组受试者的餐后胆囊排空均无影响。在用牛磺熊去氧胆酸或熊去氧胆酸治疗1个月后，胆结石患者的空腹胆囊体积进一步增加，尽管胆囊排空仍无变化。因此，治疗剂量的牛磺熊去氧胆酸或熊去氧胆酸对健康受试者或胆结石患者的餐后胆囊排空均无急性影响。用任何一种胆盐进行慢性治疗都会导致空腹胆囊体积增加，而不会影响餐后胆囊排空的程度。
