Hu M, Hao Y, Hui Y
Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an.
Zhonghua Yan Ke Za Zhi. 1995 Nov;31(6):457-9.
To approach the effect of intraocular lens implantation on the mechanism of posterior capsular opacification, the pathological changes of posterior lens capsule after intraocular lens implantation in rabbits were observed by transmission electron microscopy. The results were as follows: In the control group, 1 week after the operation and the injection of the medium of the macrophage suspension, the lens posterior capsule was covered by a layer of lens epithelium and until post-operative 6 months, the lens epithelium remained normal. In the experimental group, 1 week after the operation and the injection of the macrophage suspension into the anterior chamber, microfilaments appeared in the cytoplasm of lens epithelial cells, after 2 weeks, the lens epithelial cells produced collagen fibrils in the extracellular matrix and until postoperative 3 months, 2-3 layers of the lens epithelium proliferated in front of the posterior capsule and a large amount of collagenous fibers were formed around the cells. It is suggested that the macrophage promote the lens epithelial proliferation and the posterior capsular opacification.
为探讨人工晶状体植入对后囊膜混浊机制的影响，采用透射电子显微镜观察兔人工晶状体植入术后晶状体后囊膜的病理变化。结果如下：对照组术后1周注射巨噬细胞悬液，晶状体后囊膜被一层晶状体上皮覆盖，直至术后6个月，晶状体上皮仍保持正常。实验组术后1周向前房注射巨噬细胞悬液，晶状体上皮细胞胞质内出现微丝，2周后晶状体上皮细胞在细胞外基质中产生胶原纤维，至术后3个月，后囊膜前2 - 3层晶状体上皮增殖，细胞周围形成大量胶原纤维。提示巨噬细胞促进晶状体上皮增殖及后囊膜混浊。
