Howard M, Irarrázaval M J, Corbalán R, Morán S, Zalaquett R, Maturana G, Urzúa J, Lema G, Canessa R, López F, Larraín E
Departamento de Enfermedades Cardiovasculares, Universidad Católica de Chile, Santiago.
Rev Med Chil. 1996 Jan;124(1):37-44.
Revascularization significantly improves early and late prognosis in acute myocardial infarction and has prompted substantial changes in therapeutic stategies. We report 140 patients aged 60.3 years old (123 male) operated within 15 days of sustaining an acute myocardial infarction, between January 1984 and December 1989. Coronary angiogram showed single vessel disease in 8 (6%), double vessel disease in 32 (23%), triple vessel disease in 85 (61%) and left main vessel disease in 13 (9%). Indications for surgery were postinfarction angina in 92 patients (66%), multiple severe coronary stenoses in 18 (13%), infarction of less than six hours from onset in 16 (11%), acute angioplasty failure in 7 (5%) and cardiogenic shock in 7 (5%). Thirty one patients were operated during the initial 24 h of infarction (16 with less than 6 h), 14 between the second and third day and 95 between the fourth and fifteenth day. Overall mortality was 4.3% (6/140). Among patients with failed angioplasty and cardiogenic shock, mortality was 23% (7/140), among patients with postinfarction angina this figure was 2.1% (2/92). No patient operated within 6 hours of infarction onset or due to severe coronary stenosis, died. Ninety seven percent of patients were followed during mean of 49 months. Three patients had a new acute myocardial infarction, two had sudden death and two died of unrelated causes. One required angioplasty and none was reoperated. Five years actuarial survival was 95% and the actuarial probability of being free of acute myocardial infarction, angioplasty or reoperation at five years was 99 and 100% respectively. It is concluded that early surgical revascularization in cute myocardial infarction is safe and has excellent long term results.
血管重建术可显著改善急性心肌梗死的早期和晚期预后,并促使治疗策略发生了重大变化。我们报告了1984年1月至1989年12月期间,140例年龄为60.3岁(男性123例)的患者,他们在急性心肌梗死后15天内接受了手术。冠状动脉造影显示,单支血管病变8例(6%),双支血管病变32例(23%),三支血管病变85例(61%),左主干血管病变13例(9%)。手术指征为:92例(66%)患者为梗死后心绞痛,18例(13%)患者为多处严重冠状动脉狭窄,16例(11%)患者起病后梗死时间小于6小时,7例(5%)患者急性血管成形术失败,7例(5%)患者发生心源性休克。31例患者在梗死最初24小时内接受手术(16例梗死时间小于6小时),14例在第二天至第三天接受手术,95例在第四天至第十五天接受手术。总体死亡率为4.3%(6/140)。血管成形术失败和心源性休克患者的死亡率为23%(7/140),梗死后心绞痛患者的死亡率为2.1%(2/92)。梗死起病后6小时内接受手术或因严重冠状动脉狭窄而接受手术的患者无死亡病例。97%的患者接受了平均49个月的随访。3例患者发生了新的急性心肌梗死,2例猝死,2例死于无关原因。1例患者需要进行血管成形术,无患者接受再次手术治疗。五年精算生存率为95%,五年内无急性心肌梗死、血管成形术或再次手术的精算概率分别为99%和100%。结论是,急性心肌梗死早期手术血管重建术是安全的,且具有优异的长期效果。