Roman I C, Georgian L
Mutat Res. 1977 Apr;48(2):215-24. doi: 10.1016/0027-5107(77)90163-4.
The comparative cytogenetic effects of some widely used anti-tuberculosis drugs (PAS Na, PRA, RMA) were estimated depending on the in vitro administered concentrations, in human peripheral blood cultures. The structural chromosomal lesions were randomly distributed between the different chromosome groups of the human karyotype; nearly 10 to 30% of affected cells had more than one lesion per metaphase. In the treatements with PAS Na and PRA the analysis of the frequencies of the cell carring chromosomal aberrations and of the chromosomal lesion types indicated a dose-response correlation. The significance of the results obtained in vitro on the chromosome-breaking effects of anti-tuberculosis agents and the genetic peril is pointed out.
根据体外给药浓度，评估了一些广泛使用的抗结核药物（对氨基水杨酸钠、丙硫异烟胺、利福霉素）对人外周血培养物的比较细胞遗传学效应。结构染色体损伤随机分布在人类核型的不同染色体组之间；近10%至30%的受影响细胞每个中期有不止一个损伤。在对氨基水杨酸钠和丙硫异烟胺的处理中，对携带染色体畸变的细胞频率和染色体损伤类型的分析表明存在剂量反应相关性。指出了体外获得的关于抗结核药物染色体断裂效应和遗传风险结果的意义。
