Roman I C, Vainer E, Socosan I, Drăghicescu T
Hum Genet. 1983;63(2):191-2. doi: 10.1007/BF00291544.
Chromosome studies were carried out on the peripheral blood lymphocytes of ten tuberculosis (tb) patients receiving combined tuberculostatic chemotherapy for long intervals (3-10 months) and on those of two control groups, one of ten healthy subjects and the second of ten other tb patients in whom the tuberculostatic treatment had been discontinued 10-19 months previously. An increased proportion of aberrations, particularly chromosomal breaks and achromatic gaps, were observed in the patients under treatment, suggesting a possible synergic interaction of INH and RMA in the production of chromosomal damage.
对10名长期（3 - 10个月）接受联合抗结核化疗的肺结核（tb）患者的外周血淋巴细胞进行了染色体研究，并对两个对照组进行了研究，一个对照组由10名健康受试者组成，另一个对照组由10名其他肺结核患者组成，这些患者在10 - 19个月前已停止抗结核治疗。在接受治疗的患者中观察到畸变比例增加，特别是染色体断裂和无色间隙，这表明异烟肼（INH）和利福平（RMA）在产生染色体损伤方面可能存在协同相互作用。
