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[培氟沙星、环丙沙星、诺氟沙星和阿奇霉素对假结核耶尔森菌菌株抗菌活性的比较研究]

[Comparative study of the antimicrobial activity of pefloxacin, ciprofloxacin, norfloxacin and azithromycin with respect to Strains of Yersinia pseudotuberculosis].

作者信息

Zaĭtseva E A, Shubin F N, Besednova N N

出版信息

Antibiot Khimioter. 1996 Jan;41(1):19-21.

PMID:8762820
Abstract

Ciprofloxacin (C), pefloxacin (P) and norfloxacin (N) had a marked effect on Yersinia pseudotuberculosis strains isolated from the infected humans and animals. The activity of C (MIC 0.0312-0.125 microgram/ml) was higher than that of P and N (MIC 0.0625-2.0 micrograms/ml). The isolates were resistant to azithromycin (MIC 3.1-100 micrograms/ml). The susceptibility of the strains did not depend on the source of their isolation. The polyresistant strains carrying the R plasmids preserved the susceptibility to the fluoroquinolones.

摘要

环丙沙星(C)、培氟沙星(P)和诺氟沙星(N)对从感染人类和动物中分离出的假结核耶尔森菌菌株有显著作用。C的活性(MIC为0.0312 - 0.125微克/毫升)高于P和N(MIC为0.0625 - 2.0微克/毫升)。分离株对阿奇霉素耐药(MIC为3.1 - 100微克/毫升)。菌株的敏感性不取决于其分离来源。携带R质粒的多重耐药菌株对氟喹诺酮类药物仍敏感。

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