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[抗菌制剂对体外假结核病病原体的活性]

[Activity of antibacterial preparations against the causative agent of pseudotuberculosis in vitro].

作者信息

Vasil'ev P G, Kalininskiĭ V B, Vasil'ev N T, Iurchenko A V

出版信息

Antibiot Khimioter. 1990 Jun;35(6):29-31.

PMID:2400288
Abstract

Antibacterial activity of 32 chemotherapeutics against 15 strains of Yersinia ++pseudotuberculosis was studied in vitro. The majority of the strains or 80% were sensitive to penicillins, cephalosporins, monobactams, aminoglycosides, tetracyclins , anzamycins, fluorine derivatives of quinolonecarboxylic acid, levomycetin and a combination of trimethoprim and ++sulfamethoxazole. It was shown that with respect to the Y. pseudotuberculosis strains with multiple antibiotic resistance, the fluorine derivatives of quinolonecarboxylic acid (ciprofloxacin, norfloxacin and enoxacin), tetracyclines, netilmicin, amikacin, cefotaxime and cefazolin were promising for in vivo studies.

摘要

对32种化疗药物针对15株假结核耶尔森菌的抗菌活性进行了体外研究。大多数菌株(80%)对青霉素、头孢菌素、单环β-内酰胺类、氨基糖苷类、四环素类、安莎霉素、喹诺酮羧酸的氟衍生物、氯霉素以及甲氧苄啶和磺胺甲恶唑的组合敏感。结果表明,对于具有多重抗生素耐药性的假结核耶尔森菌菌株,喹诺酮羧酸的氟衍生物(环丙沙星、诺氟沙星和依诺沙星)、四环素类、奈替米星、阿米卡星、头孢噻肟和头孢唑林有望用于体内研究。

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