Coutard M, Osborne-Pellegrin M
INSERM U 367, Paris, France.
Int J Exp Pathol. 1996 Apr;77(2):53-62. doi: 10.1046/j.1365-2613.1996.00963.x.
Microscopic aneurysmal-like structures (ALS) develop spontaneously in the convoluted rat testicular artery and have been previously proposed as a model relevant to cerebral aneurysms. The effect of defects in connective tissue fibres on ALS formation was investigated by microscopy using two approaches: (i) the study of the effect of beta-aminopropionitrile (BAPN), an inhibitor of the cross-linking of elastic and collagen fibres, on the incidence, size and morphology of ALS in spontaneously hypertensive rats (SHR) and their normotensive controls (WKY). The straight spermatic artery was studied for comparison. (ii) The determination of the incidence of spontaneous ALS in Brown Norway (BN) and Long Evans (LE) rats which are highly susceptible (BN) or resistant (LE) to the spontaneous rupture of the arterial internal elastic lamina. (i) BAPN increased the number and size of ALS in SHR and WKY rats and had no effect on the straight spermatic artery and (ii) ALS were more numerous and of greater size in BN than in LE rats. Taken together, these results show that defective connective tissue fibres may favour the formation and induce the enlargement of aneurysmal-like structures. By analogy, these data suggest that a lack of connective tissue fibre integrity may be of importance in cerebral aneurysm formation and development.
微小动脉瘤样结构（ALS）在大鼠迂曲的睾丸动脉中自发形成，此前已被提议作为与脑动脉瘤相关的模型。通过显微镜检查，采用两种方法研究了结缔组织纤维缺陷对ALS形成的影响：（i）研究β-氨基丙腈（BAPN），一种弹性纤维和胶原纤维交联抑制剂，对自发性高血压大鼠（SHR）及其正常血压对照大鼠（WKY）中ALS的发生率、大小和形态的影响。为作比较，对直的精索动脉进行了研究。（ii）测定对动脉内弹性膜自发破裂高度敏感（BN）或有抗性（LE）的棕色挪威大鼠（BN）和长 Evans 大鼠（LE）中自发性 ALS 的发生率。（i）BAPN增加了SHR和WKY大鼠中ALS的数量和大小，对直的精索动脉无影响；（ii）BN大鼠中的ALS比LE大鼠更多且更大。综上所述，这些结果表明，结缔组织纤维缺陷可能有利于动脉瘤样结构的形成并导致其扩大。由此类推，这些数据表明结缔组织纤维完整性的缺乏可能在脑动脉瘤的形成和发展中起重要作用。
